The Francis Crick Institute Positions 2022 in London, England, United Kingdom – Senior Laboratory Research Scientist in High Through Put Screening team

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About the job

Salary: £35,500 – £42,250 dependent on skills and experience

Contact term:

This is a full-time, permanent position on Crick terms and conditions of employment.

Overview

The High Throughput Screening (HTS) facility is one of the core technology platforms available to all researchers at the Crick and enables them to use screening techniques as part of their research. Activities can include, but are not restricted to, genome-wide CRISPR and RNAi screens, large-scale cell-based screens with collections of well-characterised small molecules or proof-of-concept drug discovery screens and the development of novel screening platforms as required by researchers. For example, our recent development of a high throughput, live virus, neutralisation assay for SARS-CoV-2 which measures the ability of patient serum to prevent infection by variants of concern has been deployed to great effect (see references) and has now been spun off as a separate unit within the Crick. In addition, we use our knowledge and technologies to automate and improve current research practises e.g. making and selecting CRISPR knockout cell lines. Areas of recent expansion include genome-wide CRISPR screening with infectious agents, arrayed CRISPRa screening in human ES and small molecule screening in mouse organoid models.

Project Summary

HTS staff collaborate with researchers to create biologically relevant and informative cell-based assays for genome-wide CRISPR, siRNA or chemical screens. We also use our skills to assist in the development of smaller-scale assays, create reagents for novel assays, collaborate to improve research techniques and collaborate with internal and external pharma partners to perform proof of concept or early-stage drug discovery screens. HTS staff interact with a vast range of biological research in the institute and we try to make it possible to pose research questions that might otherwise seem daunting or impossible. This position will require you to collaborate with researchers to create, plan and conduct large-scale screens while balancing a number of other projects at different levels of development simultaneously. This is an opportunity to use your accumulated biology knowledge and curiosity about other areas of biology as well as your skills at the bench and desire to try new things towards creating the most informative and valuable research data possible. You will work with highly experienced colleagues and collaborators in an institute that values discovery without boundaries.

Key Responsibilities

These include but not limited to;

• Running multiple screening projects simultaneously
• Creating and perfecting bespoke assays that provide researchers with reliable and interpretable data
• Exploring new techniques and assimilating unfamiliar biological knowledge when necessary
• Managing workload and maintaining a good working relationship with all collaborators
• Keep up to date with work in the institute and be proactive in looking for opportunities where the HTS could be of benefit to researchers

Key experience and competencies

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Essential

• Extensive direct experience in using cell-based assays, tissue culture and immunofluorescence-staining techniques
• Previous direct experience of HTS campaigns in either Pharma or academia preferably using arrayed CRISPR, RNAi or small molecule reagents would be extremely advantageous
• Experience with high throughput screening techniques and associated machinery particularly automated microscope and High Content Analysis would be extremely advantageous
• Able to maintain a productive dialogue with facility users and educate users in techniques and use of specific machines for high throughput screening
• Ability to quickly understand and appreciate unfamiliar areas of biology in order to create the best assay possible with users
• Capable of self-teaching, innovating and problem solving
• Self-motivated with the ability to work both independently and as part of a team
• Excellent organisation and communication skills

Desirable:

• Familiarity with a wide range of research techniques and biological systems
• Post-doctoral research experience or extensive relevant experience in Pharma a distinct advantage
• Previous experience with fragment and small molecule screening would be advantageous
• Demonstrable organisational skills and attention to detail, with the ability to prioritise own workload.
• Excellent inter-personal skills and a willingness to learn new skills and teach these to others
• Previous experience of service provision would be advantageous

References

Carr et al. Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients. The Lancet. 2021.

https://doi.org/10.1016/S0140-6736(21)01854-7

Faulkner et al. Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains. Elife. 2021;10.

https://www.ncbi.nlm.nih.gov/pubmed/34323691

Fendler et al. Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study. Nature Cancer. 2021.

https://doi.org/10.1038/s43018-021-00275-9

Fendler et al. Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study. Nature Cancer. 2021.

https://doi.org/10.1038/s43018-021-00274-w

Wall et al. AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC. The Lancet. 2021.

https://doi.org/10.1016/S0140-6736(21)01462-8

Wall et al. Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination. The Lancet. 2021.

https://www.sciencedirect.com/science/article/pii/S0140673621012903

Company: The Francis Crick Institute

Vacancy Type: Full-time · Associate

Job Location:  London, England, United Kingdom

Application Deadline: N/A

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